Bacteriophage products

Eliava BioPreparations

Location: Georgia

The following is a list of available bacteriophages:

  • PYO Bacteriophage – a mix of sterile lysate phages against; Staphylococcus aureus, Streptococcus (S.pyogenes, S. sanguis, S.salivarius and S. agalactiae), Escherichia coli (different types), Pseudomonas aeruginosa and Proteus (P. mirabilis and P. vulgaris) spices.
  • Intesti Bacteriophage – a mix of sterile lysate phages against; Shigella flexneri (serotypes 1,2,3,4; S. sonnei; Shigella newcastle type), Salmonella (Salmonella paratyphi A, B, S. typhimurium, S. enteritidis, S. choleraesuis and S. oranienburg), Escherichia coli, Proteus (P. vulgaris and P. mirabilis); Staphylococcus aureus, Pseudomonas aeruginosa and Enterococcus faecalis.
  • Staphylococcal Bacteriophage – a mix of sterile lysate phages against; Staphylococcus aureus spices.
  • SES Bacteriophage – a mix of sterile lysate phages against; Staphylococci, Streptococci and Enteropathogenic Escherichia coli of different serovars.
  • FERSISI Bacteriophage – a mix of sterile lysate phages against; Staphylococci and Streptococci.
  • ENKO Bacteriophage – a mix of sterile lysate phages against; Staphylococcus, Shigella, Escherichia coli and Salmonella of different serovars.

Biochimpharm

Location: Georgia

The following is a list of available bacteriophages:

  • PHAGYO – a mix of sterile lysate phages against; Streptococcus, Staphylococcus, Escherichia coli, Pseudomonas aeruginosa, Proteus and their combinations.
  • PHAGYO spray – a mix of sterile lysate phages against; Streptococcus, Staphylococcus, Escherichia coli, Pseudomonas aeruginosa and Proteus.
  • Septaphage – a mix of sterile lysate phages against; Shigella (S. flexneri 1,2,3,4,6 serogroup and S. sonnei), Salmonella (Salmonella paratyphi A, B, S. typhimuriumS. choleraesuis, S. oranienburg and S. enteritidis), Enteropathogenic Escherichia coli etiologically important serogroups of enteral diseases, Proteus (P. vulgaris and P. mirabilis), Staphylococcus, Pseudomonas and Enterococcus.
  • PHAGESTAPH – a mix of sterile lysate phages against; Staphylococcus aureus.
  • Septaphage tablets – ­­tablets containing liophylically dried phagolysates against; Shigella (S. flexneri 1,2,3,4,6 serogroup and S. sonnei), Salmonella (Salmonella paratyphi A, B, S. typhimuriumS. choleraesuis, S. oranienburg and S. enteritidis), Enteropathogenic Escherichia coli – etiologically important serogroups of enteral diseases, Proteus (P. vulgaris and P. mirabilis), Staphylococcus, Pseudomonas and Enterococcus.
  • Travelphage – capsules containing liophylically dried phagolysates against; Shigella, Salmonella, Escherichia coli, Proteus, Staphylococcus, Pseudomonas and Enterococcus. As well as conditions caused by the unity of the mentioned bacteria such as; shigelosis, typhoid, paratyphoid, dysbacteriosis, enterocolitis, acute and chronic colitis, dyspepsia in complex therapy and foodborne infections.

Microgen

Location: Russia

The following is a list of available bacteriophages:

  • E.coli-Proteus bacteriophage – a mix of sterile lysate phages against; Escherichia coli and Proteus.
  • Streptococcus bacteriophage – a mix of sterile lysate phages against; Streptococcus.
  • E.coli bacteriophage – a mix of sterile lysate phages against; Escherichia coli.
  • Complex PYOBacteriophage – a mix of sterile lysate phages against; Staphylococci, Streptococci, Enterococci, Proteus, Klebsiella pneumoniae and Klebsiella oxytoca, Pseudomonas aeruginosa and Escherichia coli.
  • Klebsiella purified polyvalent Bacteriophage – a mix of sterile lysate phages prevention against hospital-acquired infections caused by Klebsiella.
  • Sextaphag polyvalent PYOBacteriophage – a mix of sterile lysate phages against; a mix of sterile lysate phages against; Staphylococci, Streptococci (including Enterococci), Proteus, Klebsiella pneumoniae, Pseudomonas aeruginosa and Escherichia coli.
  • Dysentery Bacteriophage – a mix of sterile lysate phages against; Shigella flexneri of 1, 2, 3, 4, 6 serovariants and Shigella sonnei.
  • Intesti Bacteriophage – a mix of sterile lysate phages against; Salmonella, Escherichia coli, Proteus, Enterococci, Staphylococci, Pseudomonas aeruginoza or a combination thereof.

Micromir

Location: Russia

The following is a list of available bacteriophage products:

  • Phagodent – a gel for gums which contains 72 bacteriophages against; Aggregatibacter
    actinomycetemcomitans, Acinetobacter baumannii, Enterococcus faecalis, Enterobacter cloacae, Enterobacter kobei, Porphyromonas gingivalis, Prevotella intermedia, Proteus vulgaris, Proteus mirabilis, Micrococcus luteus, Stenotrophomonas maltophilia, Staphylococcus caprae, Staphylococcus succinus, Streptococcus mitis, Streptococcus mutans, Streptococcus parasanguinis, Enterococcus faecium (formerly called group D Streptococci), Streptococcus salivarius, Streptococcus agalactiae, Klebsiella spp., Klebsiella pneumoniae, Klebsiella ozanae, Wolinella spp., Propionibacterium acnes, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus hominis, Staphylococcus warneri, Staphylococcus haemolyticus and Staphylococcus capitis. Used to normalize the microflora of the oral cavity and to helps prevent the development of inflammatory diseases in the oral cavity.
  • Phagoderm – a gel for skin which contains 64 bacteriophages against; Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus hominis, Staphylococcus warneri, Staphylococcus haemolyticus, Staphylococcus capitis, Staphylococcus caprae, Staphylococcus suсcinus, Corynebacterium spp., Enterobacter spp., Enterococcus faecalis, Acinetobacter baumannii, Stenotrophomonas maltophilia, Citrobacter freundii, Propionibacterium acnes, Pseudomonas aeruginosa, Klebsiella spp., Proteus vulgaris, Proteus mirabilis, Escherichia coli and Enterococcus faecium (formerly called group D Streptococci Enterococcus faecium). Used to normalize the microflora of the skin and soft tissues and helps prevent bacterial infections of the skin.
  • Phagogyn – a gel for the area of intimate hygiene which contains 74 bacteriophages against;  Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus hominis, Staphylococcus warneri, Staphylococcus haemolyticus, Staphylococcus capitis, Staphylococcus caprae, Staphylococcus suсcinus, Gardnerella vaginalis, Pseudomonas aeruginosa, Enterobacter cloacae, Prevotella spp., Enterococcus faecalis, Acinetobacter baumannii, Stenotrophomonas maltophilia, Citrobacter freundii, Propionibacterium acnes, Klebsiella spp., Proteus vulgaris, Proteus mirabilis, Escherichia coli, Actinomyces spp., Streptococcus agalactiae, Enterococcus faecium (formerly called group D Streptococci), Enterobacter spp and Enterobacter kobai. Used to normalize the microflora of the intimate area and helps prevent bacterial disease of the reproductive system.
  • Otophagus – a gel for ENT which contains 69 bacteriophages against; Bacteroides, Bacteroides spp., Acinetobacter baumannii, Enterococcus faecalis, Enterobacter cloacae, Enterobacter kobei, Proteus vulgaris, Proteus mirabilis, Micrococcus luteus, Stenotrophomonas maltophilia, Klebsiella pneumoniae, Staphylococcus caprae, Staphylococcus suсcinus, Streptococcus mitis, Streptococcus mutans, Streptococcus parasanguinis, Enterococcus faecium (formerly called group D Streptococci Enterococcus faecium), Streptococcus salivarius, Streptococcus agalactiae, Klebsiella ozanae, Wolinella spp., Propionibacterium acnes, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus hominis, Staphylococcus warneri, Staphylococcus haemolyticus and Staphylococcus capitis. Used to normalize the microflora in ENT organs and helps prevent bacterial pyoinflammatory diseases of ear, nose and throat.

The following is a list of available bacteriophages for Vetinary use:

  • Bronchophage – a sterile suspension which contains a complex of bacteriophages against; Staphylococcus aureus, Staphylococcus epidermidis, Providencia rettgeri, Enterobacter kobei, Citrobacter freundii, Bacteroides fragilis, Propionibacterium acnes, Streptococcus pyogenes, Streptococcus haemolyticus, Salmonella enteritidis, Salmonella typhimurium, Salmonella infantis, Wolinella spp., Treponema denticola, Aggregatibacter actinomycetemcomitans, Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Proteus mirabilis, Moraxella cataralis and Enterococcus faecalis. Used for the prevention and treatment against common bacteria associated with diseases of the lower respiratory tract including in combination therapy of chronic obstructive bronchitis and chronic obstructive pulmonary disease in horses.
  • Vetagyn – a sterile suspension which contains a complex of bacteriophages against; Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus vulgaris, Staphylococcus aureus and Streptococcus pyogenes. Used for the prevention of bacterial endometritis, pyometritis and myometritis in cows.
  • Phagovet – a concentrated suspension for oral use which contains a complex of bacteriophages against; Staphylococcus aureus, Enterobacter cloacae, Citrobacter freundii, Streptococcus pyogenes, Staphylococcus haemolyticus, Salmonella enteritidis, Salmonella typhimurium, Salmonella infantis, Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, Clostridium perfringens, Klebsiella pneumoniae, Proteus vulgaris, Proteus mirabilis, Moraxella cataralis, Bacillus cereus and Bacillus mesentericus. Used for the prevention of bacterial diseases at farming broilers, rearing flocks and adult flocks.

NeoProbioCare Inc.

Location: Ukraine

The following is a list of available bacteriophages:

  • Pyofag – a solution in vial with bacteriophages against; Streptococcus pyogenes, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Proteus (P. vulgaris and P. mirabilis).
  • Intestifag – a solution in vial with bacteriophages against; Shigella (S. flexneri and S. sonnei), Salmonella enterica, Escherichia coli, Pseudomonas aeruginosa, Proteus (P. vulgaris and P. mirabilis), Enterococcus faecalis and Staphylococcus aureus.

Intralytix

Location: USA

The following is a list of available bacteriophages for Food Safety products:

  • ListShield – targets Listeria monocytogenes.
  • EcoShield – targets Escherichia coli.
  • SalmoFresh – targets highly pathogenic Salmonella-serotypes.
  • ShigaShield – targets Shigella including three major species; S. flexneri, S. sonnei and S. dysenteriae.

The following is a list of available bacteriophages for Pet Food Safety products:

  • Ecolicide – targets Escherichia coli O157:H7.
  • SalmoLyse – targets Salmonella.
  • ListPhage – targets Listeria monocytogenes.

The following is a list of available bacteriophages for Pre-Harvest Interventions products:

  • Ecolicide PX – targets Escherichia coli O157:H7.

Micreos – PhageGuard

Location: Wageningen, Netherlands

The following is a list of available bacteriophages for Food Safety products:

Meat, Poultry, Fruit & Vegetables

  • PhageGuard E – ­­ an FDA-approved, natural and clean label antimicrobial bacteriophage solution against Escherichia coli 0157, without affecting taste, odor or texture.
  • PhageGuard S – ­­an FDA-approved, natural and clean label antimicrobial bacteriophage solution against Salmonella, without affecting taste, odor or texture.
  • PhageGuard Listex – ­­ an FDA-approved, natural and clean label antimicrobial bacteriophage solution against Listeria monocytogenes, without affecting taste, odor or texture.

Cheese, Fish & Seafood

  • PhageGuard Listex – ­­ an FDA-approved, natural and clean label antimicrobial bacteriophage solution against Listeria monocytogenes, without affecting taste, odor or texture.

The following is a list of available bacteriophages for Pet Food producers:

  • PhageGuard E – an FDA-approved, natural and clean label antimicrobial bacteriophage solution against Escherichia coli 0157, without affecting taste, odor or texture.
  • PhageGuard S – an FDA-approved, natural and clean label antimicrobial bacteriophage solution against Salmonella, without affecting taste, odor or texture.
  • PhageGuard Listex – an FDA-approved, natural and clean label antimicrobial bacteriophage solution against Listeria monocytogenes, without affecting taste, odor or texture.

The following is a list of available bacteriophages for Food Contact Surfaces:

  • PhageGuard Listex – an FDA-approved, natural and clean label antimicrobial bacteriophage solution against Listeria monocytogenes, without affecting taste, odor or texture.

Proteon Pharmaceuticals

Location: Łódź, Poland

The following is a list of available bacteriophages for Animals:

Poultry

  • BAFASAL – ­­ A regulatory-approved food additive against most serotypes of Salmonella bacteria in poultry, including human pathogenic S. Enteritidis and S. Typhimurium. Used prophylactically in the prevention of infection or, in case of a suspected infection, eliminates Salmonella infection. Furthermore, given to poultry mixed with water, it is easy to apply and use.

The following is a list of available bacteriophages for Aquaculture:

  • BAFADOR – ­­a bacteriophage cocktail against Pseudomonas and Aeromonas infections in commercial aquaculture and a stimulant of the immune system of fish. Used against infection as well as for prophylactic prevention of infection.

JAFRAL

Location: Ljubljana, Slovenia

JAFRAL is a global leading independent Contract Manufacturing Organization and Contract Research Organization for manufacturing different types of phage products. The company was established in 2011 and since then has successfully marketed phage manufacturing to many countries (UK, GER, US, FRA, CN, BEL, etc.). The application spectre varies from food industry, diagnostics, cosmetics, veterinary and human health. JAFRAL has worked with all pathogenic bacteria that WHO declared them most problematic (ESKAPE bacteria) and also many others. Some of them are: Listeria, Salmonella, Campylobacter, Propionibacterium, E.coli, Pseudomonas, Staphylococcus, Klebsiella and Clostridium. JAFRAL is works with natural and GMO phages.

The following is a list the broad spectrum of services offered by JAFRAL:

  • Production of R&D quality of phage products
  • Production of pre-clinical quality of phage products
  • Production of clinical trial quality (GMP) of phage products
  • Production of phage products used for compassionate use cases.

JAFRAL also offers all testing for all quality control parameters that are relevant for various quality of phage products; Potency, Endotoxins, DNA concentration, HCP, TFU and more.

Products based on bacteriophages

Micreos – Staphefekt

Location: Bilthoven, Netherlands

Staphefekt­­ focuses on the use of endolysins, bacteria-killing enzymes that originate from bacteriophages, to target Staphylococcus aureus and strains that are resistant to antibiotics, such as MRSA.

The following is a list of available products based on bacteriophages:

  • Gladskin Acne – treatment for acne in the form of a ­­gel, cleaning set, moisturizing set or care set containing Staphefekt­­ and targets Staphylococcus aureus.
  • Gladskin Eczema – treatment for eczema in the form of a ­­gel or cream containing Staphefekt­­ and targets Staphylococcus aureus.
  • Gladskin Rosacea – treatment for rosacea in the form of a ­­gel, cream, day & night set, cleansing set, moisturizing set or care set containing Staphefekt­­ and targets Staphylococcus aureus.
  • Gladskin Shaving Irritation – treatment against shaving irritation of the skin in the form of a ­­gel, cleansing set, moisturizing set or care set containing Staphefekt­­ and targets Staphylococcus aureus.

Products containing bacteriophages

Enviromedica

Location: Austin, USA

Terraflora Advanced Care uses a synbiotic approach of bacteriophages together with probiotics and prebiotics to provide an appropriate microbial balance and support for a healthy GI tract.

The following is a list of available products containing bacteriophages:

  • Terraflora Advanced Care – capsules containing;
    • Phage Bio-Complex – 15mg – LH01-Myoviridae, LL5-Siphorviridae, T4D-Myoviridae and LL12-Myoviridae.
    • Probiotic Bio-Complex – 1 Billion Viable Cells per serving – Ribospore® (Bacillus pumilus). Bacillus megaterium EM144™, Bacillus subtilis, Bacillus clausii and Bacillus coagulans.
    • Prebiotic Bio-Complex – 850mg per serving – Larch Arabinogalactan (Larix spp.), Reishi (Ganoderma lucidum) extract, Wild-Harvested Chaga (Inonotus obliquus) extract, Wild-Harvested Nova Scotian Bladderwrack (Fucus vesiculosus) extract (thallus), Wild-Harvested Patagonian Wakame (Undaria pinnatifida) extract (sporophyll) and Humic Acids.

Neopharm

Location: Georgia

The following is a list of available products containing bacteriophages:

  • PhagoBioDerm – application film composed of; Ciprofloxacin hydrochloride, anesthesin (benzocaine),
    Pyophage, proteolytic enzyme (chymotrypsin), and biodegradable polymer. Used for the stimulation of regeneration of tissue.

Viera

Location: Russia

The following is a list of available products containing bacteriophages:

  • Hygenic spray – odorless spray with bacteriophages against; Proteus mirabilis spp., Bacteroides spp., Citrobacter freundii spp., Corynebacterium spp., Actinomyces spp., Staphylococcus aureus spp., Staphylococcus epidermidis spp., Streptococcus pyogenes spp., Escherichia coli spp., Pseudomonas aeruginosa spp., Proteus vulgaris spp., Klebsiella pneumoniae spp., Neisseria spp., Moraxella catarrhalis spp., Shigella spp., Bacillus cereus spp., Bacillus thuringiensis spp., Acinetobacter baumannii, Staphylococcus hominis and Staphylococcus succinus.  Used on face, hands, and household items, as well as sprayed into the air during bacterial infections.
  • Hand spray – spray with prebiotics and bacteriophages against; Enterobacter spp., Bacteroides fragilis, Staphylococcus aureus spp., Citrobacter freundii, Streptococcus pyogenes spp., Escherichia coli spp., Bacteroides spp., Proteus vulgaris spp., Pseudomonas aeruginosa spp., Porfiromonas gingivalis, Klebsiella spp., Proteus mirabilis spp., Staphylococcus epidermidis spp., Corynebacterium spp., Bacillus cereus spp., Bacillus mesentericus spp., Streptococcus haemolyticus spp., Acinetobacter baumannii and Staphylococcus haemolyticus. Used on hands, acts as antibacterial protection and is effective for skin lesion healing.
  • Foot spray – spray with prebiotics and bacteriophages against; Enterobacter spp., Bacteroides fragilis, Escherichia coli spp., Citrobacter freundii, Staphylococcus aureus spp., Pseudomonas aeruginosa spp., Bacteroides spp., Streptococcus pyogenes spp., Proteus vulgaris spp., Enterococcus faecalis, Klebsiella spp., Proteus mirabilis spp., Staphylococcus epidermidis spp. and Propionibacterium acnes. Used on feet, acts as antibacterial protection, and is effective for healing.
  • Oral cavity spray – spray with prebiotics and bacteriophages against; Wolinella spp., Porfiromonas gingivalis, Staphylococcus aureus, Actinomyces spp., Campylobacter spp., Streptococcus pyogenes, Actinobacillus actinomycetemcomitans, Bacteroides spp., Streptococcus mutans, Pseudomonas aeruginosa, Proteus vulgaris, Klebsiella spp. and Staphylococcus caprae. Used to prevent harmful bacteria to manifest on teeth, tongue, and nasopharynx.
  • Spray for women – spray with prebiotics and bacteriophages against; Acinetobacter baumannii spp., Bacteroides spp., Citrobacter freundii spp., Actinomyces spp., Enterobacter cobei, Enterococcus faecalis, Enterobacter cloacae, Escherichia coli spp., Gardnerella vaginalis, Hafnia alvei spp., Klebsiella ozanae, Klebsiella pneumoniae, Propionibacterium acne, Proteus mirabilis spp., Proteus vulgaris spp., Pseudomonas aeruginosa spp., Staphylococcus capitis, Staphylococcus caprae, Staphylococcus epidermidis spp., Staphylococcus haemolyticus, Staphylococcus succinus, Staphylococcus warneri, Stenotrophomonas maltophilia, Streptococcus agalactiae, Streptococcus haemolyticus spp., Streptococcus pyogenes and Streptococcus group D spp. Used to prevent and fight against pathogenic bacteria, leaving useful microflora.
  • Spray for men– spray with prebiotics and bacteriophages against; Proteus mirabilis spp., Staphylococcus epidermidis spp., Staphylococcus aureus spp., Corynebacterium spp., Actinomyces spp., Streptococcus pyogenes spp., Bacteroides spp., Pseudomonas aeruginosa spp., Escherichia coli spp., Citrobacter freundii spp., Propionibacterium acnes, Staphylococcus epidermidis and Proteus vulgaris spp. Used to prevent and fight against pathogenic bacteria, leaving useful microflora.

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