Clinical Trials

Bacteriophage Therapy for Methicillin-Sensitive Staphylococcus Aureus Prosthetic Joint Infection

Trial ID: NCT06456424   Registry: ClinicalTrials.gov

Intervention: Phage therapy

Condition: Prosthetic Joint Infections of Hip, Staphylococcus Aureus Infection

Sponsor: University of Calgary

Locations: 1 active-listed location

Bacteriophage Therapy for Morganella Morganii Prosthetic Joint Infection

Trial ID: NCT06814756   Registry: ClinicalTrials.gov

Intervention: phage therapy

Condition: Prosthetic Joint Infections of Hip

Sponsor: University of Calgary

Locations: 1 active-listed location

Bacteriophage Therapy in Tonsillitis

Trial ID: NCT04682964   Registry: ClinicalTrials.gov

Intervention: Nebulizer inhalation irrigation of the mucous membranes of the tonsils with a bacteriophage.

Condition: Acute Tonsillitis

Sponsor: Tashkent State Medical University (Tashkent Pediatric Medical Institute), Uzbekistan

Locations: 1 active-listed location

Safety and Efficacy of EcoActive on Intestinal Adherent Invasive E. Coli in Patients With Inactive Crohn's Disease

Trial ID: NCT03808103   Registry: ClinicalTrials.gov

Intervention: Placebo, Bacteriophage preparation

Condition: Crohn Disease

Sponsor: Intralytix, Inc.

Locations: 2 active-listed locations

Safety and Efficacy of the Bacteriophage Preparation, ShigActive™, in a Human Experimental Model of Shigellosis

Trial ID: NCT05182749   Registry: ClinicalTrials.gov

Intervention: bacteriophage, Placebo

Condition: Shigellosis

Sponsor: Intralytix, Inc.

Locations: 1 active-listed location

Use of Phage Therapy for Treatment of a Periprosthetic Joint Infection

Trial ID: NCT06827041   Registry: ClinicalTrials.gov

Intervention: Phage (Cytophage Technologies)

Condition: Periprosthetic Joint Infection

Sponsor: Ottawa Hospital Research Institute

Locations: 1 active-listed location

Bacteriophage Therapy for Mycobacterium Abscessus Pulmonary Infection

Trial ID: NCT07228702   Registry: ClinicalTrials.gov

Intervention: Mycobacteriophage Muddy_HRMN0052, Amikacin Injection, Clofazimine, Bedaquiline (B), Linezolid (LZD), Sulfamethoxazole/Trimethoprim, Imipenem + Cilastatin, Ceftaroline fosamil, Omadacycline Oral Tablet

Condition: Non-Tuberculous Mycobacterial (NTM) Pneumonia, Mycobacterium Abscessus Infection

Sponsor: Vancouver Coastal Health

Locations: 1 active-listed location

Mayo Clinic Phage Program Biobank

Trial ID: NCT05314426   Registry: ClinicalTrials.gov

Condition: Bacteriophage Therapy

Sponsor: Mayo Clinic

Locations: 1 active-listed location

Mycobacteriophage Treatment of Non-tuberculosis Mycobacteria

Trial ID: NCT06262282   Registry: ClinicalTrials.gov

Intervention: mycobacteriophage

Condition: Cystic Fibrosis, Nontuberculous Mycobacterial Lung Disease, Nontuberculous Mycobacterium Infection, Mycobacterium Infections, Mycobacterium; Pulmonary

Sponsor: National Jewish Health

Locations: 18 active-listed locations

Randomized Controlled Study on the Safety and Efficacy of Phage Cocktail in the Treatment of Multidrug-Resistant Bacterial Skin Infections

Trial ID: NCT07619924   Registry: ClinicalTrials.gov

Intervention: Bacteriophage Treatment, Placebo treatment using 0.9% normal saline

Condition: Phage Therapy, Bacteriophage Therapy, Skin and Soft Tissue Infections

Sponsor: First Affiliated Hospital Xi'an Jiaotong University

Locations: 1 active-listed location

"Debridement PhagE AnTibiotics for PJI"

Trial ID: NCT07698002   Registry: ClinicalTrials.gov

Intervention: The investigational product specifically targeting P. aeruginosa (DP-QB-PSA-005) and that targeting S. aureus (DP-QB-STA-005), each formed of a mixture of 5 bacteriophages.

Condition: Periprosthetic Infection

Sponsor: Ottawa Hospital Research Institute

Locations: 1 active-listed location

A Double-Blind, Placebo-Controlled Study of Nebulized Bacteriophages in Patients With Ventilator-Associated Pneumonia Due to Pseudomonas Aeruginosa

Trial ID: NCT07804082   Registry: ClinicalTrials.gov

Intervention: Bacteriophages GMP, saline solution (placebo)

Condition: Ventilator Associated Bacterial Pneumonia, Pseudomonas Aeruginosa Infection

Sponsor: Assistance Publique - Hôpitaux de Paris

Locations: 16 active-listed locations

A Randomized Controlled Trial (RCT) of Yiqi Huoxue Jiedu Formula Combined With Bacteriophages in the Treatment of Severe Pneumonia Caused by Drug-resistant Gram-negative Bacilli

Trial ID: NCT07338123   Registry: ClinicalTrials.gov

Intervention: YHDF Drug, YHDF Placebo, Bacteriophage, Bacteriophage Placebo

Condition: Pneumonia

Sponsor: Chinese PLA General Hospital

Bacteriophage Cocktail Therapy for Multidrug-Resistant Gram-Negative Ventilator-Associated Pneumonia

Trial ID: NCT07202234   Registry: ClinicalTrials.gov

Intervention: Phage cocktail administered via nebulization, Nebulized normal saline inhalation therapy

Condition: VAP - Ventilator Associated Pneumonia

Sponsor: Chinese PLA General Hospital

Bacteriophage Therapy for Orthopedic Implant-Associated Infections

Trial ID: NCT07533292   Registry: ClinicalTrials.gov

Intervention: bacteriophage preparation

Condition: Orthopedic, Implant Infection

Sponsor: Second Affiliated Hospital, Zhejiang University, School of Medicine

Locations: 1 active-listed location

Bacteriophage Therapy for Staphylococcus Lugdunensis Prosthetic Joint Infection

Trial ID: NCT07461337   Registry: ClinicalTrials.gov

Intervention: Five phage anti-Staphylococcus aureus bacteriophage cocktail

Condition: Prosthetic Joint Infections of Hip, Bacteriophage Therapy

Sponsor: University of Calgary

Locations: 1 active-listed location

Bacteriophage for Chronic Multidrug-Resistant Mycobacterium Abscessus Subsp. Abscessus Pulmonary Infection

Trial ID: NCT07429162   Registry: ClinicalTrials.gov

Intervention: DP-QB-MYA-002

Condition: Mycobacterium Abscessus Infection, Bacteriophage Therapy, Pulmonary Disease

Sponsor: Alberta Health services

Evaluation of Safety and Efficacy of Phage Therapy for Drug-resistant Bacterial Infections: An Exploratory, Prospective Single-arm Study

Trial ID: NCT07382271   Registry: ClinicalTrials.gov

Intervention: Personalized Phage Cocktail

Condition: Urinary Tract Infections, Urinary Tract Infections Caused by Drug-resistant Bacteria

Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

OPTImization of Inflammatory Bowel Disease Treatment Through Understanding of Gut VIRome Heterogeneity

Trial ID: NCT07240181   Registry: ClinicalTrials.gov

Condition: IBD (Inflammatory Bowel Disease), Crohns Disease, Colitis Ulcerative

Sponsor: Andreas Munk Petersen

Locations: 1 active-listed location

Phage Therapy for the Treatment of a Chronic Enterococcus Faecium Periprosthetic Joint Infection

Trial ID: NCT06942624   Registry: ClinicalTrials.gov

Intervention: Phage Therapy

Condition: Periprosthetic Joint Infection

Sponsor: Orthopaedic Innovation Centre

Locations: 1 active-listed location

Proof of Concept Study to Assess Safety and Efficacy of Phage Therapy in Hip or Knee Prosthetic Joint Infections Due to Staphylococcus Aureus Treated by DAIR.

Trial ID: NCT06605651   Registry: ClinicalTrials.gov

Intervention: Anti-Staphylococcus aureus Bacteriophages (PP1493 and PP1815) intra-articular injection with 0.9% NaCl solution, 0.9% NaCl solution

Condition: Hip Prosthesis Infection, Knee Prosthesis Infection

Sponsor: Phagenix

Safety and Tolerability of NTR-101 in Patients With Acute Alcohol-Associated Hepatitis

Trial ID: NCT06750588   Registry: ClinicalTrials.gov

Intervention: bacteriophage preparation, Bacteriophage preparation

Condition: Alcohol-Associated Hepatitis

Sponsor: Nterica Bio inc

Locations: 1 active-listed location

Safety of Combined Intravenous Antibiotic and Bacteriophage Therapy in Adults With Cystic Fibrosis and Antibiotic-Resistant Lung Infections

Trial ID: NCT07280598   Registry: ClinicalTrials.gov

Intervention: Intravenous Bacteriophage Cocktail plus Standard IV Antibiotics

Condition: CF - Cystic Fibrosis, Klebsiella Pneumoniae Infection, E Coli Infections, Staphylococcus Aureus Infection, Achromobacter, Stenotrophomonas Maltophilia Infection

Sponsor: University of California, San Diego

Standard Treatment Associated With Phage Therapy Versus Placebo for Diabetic Foot Ulcers Infected by S. Aureus

Trial ID: NCT02664740   Registry: ClinicalTrials.gov

Intervention: Topical anti-Staphylococcus bacteriophage therapy, Topical placebo corresponding to anti-Staphylococcus bacteriophage therapy

Condition: Diabetic Foot, Staphylococcal Infections

Sponsor: Centre Hospitalier Universitaire de Nīmes

Locations: 6 active-listed locations

Yiqi Huoxue Jiedu Formula Combined With Bacteriophages in the Treatment of Severe Pneumonia

Trial ID: NCT07612605   Registry: ClinicalTrials.gov

Intervention: YHDF placebo, Bacteriophage Placebo, YHDF Drug, Bacteriophage

Condition: Pneumonia

Sponsor: Chinese PLA General Hospital

Locations: 4 active-listed locations

A Study of LBP-EC01 in the Treatment of Acute Uncomplicated UTI Caused by Drug Resistant E. Coli (ELIMINATE Trial)

Trial ID: NCT05488340   Registry: ClinicalTrials.gov

Intervention: LBP-EC01 0.1 x IV dose, LBP-EC01 0.01x IV Dose, LBP-EC01 IV Infusion Dose, Placebo, LBP-EC01, TMP/SMX

Condition: Urinary Tract Infections

Sponsor: Locus Biosciences

Locations: 17 active-listed locations

Avis-PHAGEinLYON Clinic

Trial ID: NCT05883995   Registry: ClinicalTrials.gov

Intervention: Phage therapy requests

Condition: Bone Infection

Sponsor: Hospices Civils de Lyon

Locations: 1 active-listed location

Bacteriophage Therapy in Spinal Cord Injury Patients With Bacteriuria

Trial ID: NCT06559618   Registry: ClinicalTrials.gov

Intervention: Phage Therapy, Placebo

Condition: Bacteriuria, Spinal Cord Injuries, Asymptomatic Bacteriuria, Escherichia Coli

Sponsor: Barbara Trautner

Locations: 2 active-listed locations

Bacteriophages for Adults With Cystic Fibrosis and Chronic Achromobacter Lung Infection

Trial ID: NCT07275905   Registry: ClinicalTrials.gov

Intervention: AchromoPhage

Condition: Cystic Fibrosis (CF), Achromobacter Infection

Sponsor: Ghady Haidar

Locations: 2 active-listed locations

Bacteriophages in Addition to Antibiotics for the Treatment of Patients With Infective Endocarditis

Trial ID: NCT06870409   Registry: ClinicalTrials.gov

Intervention: Bacteriophage

Condition: Endocarditis, Bacterial

Sponsor: University Clinical Hospital na V.V.Vinogradov (branch of RUDN university na Patrice Lumumba)

Locations: 1 active-listed location

Biomarkers of Phage Treatment Response in NTM and Other Infections

Trial ID: NCT07076238   Registry: ClinicalTrials.gov

Intervention: Bacteriophage Treatment

Condition: Nontuberculous Mycobacterial Lung Disease

Sponsor: NYU Langone Health

Locations: 1 active-listed location

Collection of Stool From Healthy Donors for the ex Vivo Study of Shifts of Microbiome Induced by Dairy Phages and Antibiotics: a Model of Bacteria/Host Interaction (DAIRY-SHAPE)

Trial ID: NCT07212400   Registry: ClinicalTrials.gov

Condition: General Population (no Specific Condition or Disease)

Sponsor: Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Locations: 1 active-listed location

First-in-man Single-dose and Multiple Dose Study to Evaluate the Safety, Tolerability and Efficacy ofHY-133

Trial ID: NCT06290557   Registry: ClinicalTrials.gov

Intervention: HY_133, Placebo

Condition: Staphylococcus Aureus

Sponsor: University Hospital Tuebingen

Locations: 2 active-listed locations

French National MICMAF Cohort

Trial ID: NCT05895890   Registry: ClinicalTrials.gov

Intervention: Sequential sampling (stool, saliva, serum) .

Condition: Alcoholic Liver Disease

Sponsor: Assistance Publique - Hôpitaux de Paris

Locations: 1 active-listed location

PHAGEinLYON Clinic Cohort Study: a Descriptive Study of Severe Infections Treated With Phage Therapy at the HCL.

Trial ID: NCT06185920   Registry: ClinicalTrials.gov

Intervention: Description of severe infection

Condition: Severe Infection

Sponsor: Hospices Civils de Lyon

Locations: 1 active-listed location

Phage II Trial of Stathmin as Predictive Biomarker for TPF Induction Chemotherapy in OSCC

Trial ID: NCT03326947   Registry: ClinicalTrials.gov

Intervention: docetaxel, cisplatin and 5-fluorouracil

Condition: Neoplasm Neck

Sponsor: Shanghai Jiao Tong University School of Medicine

Locations: 1 active-listed location

Phage Safety Cohort Study

Trial ID: NCT04650607   Registry: ClinicalTrials.gov

Intervention: Adverse event after injection of phages

Condition: Prosthetic Joint Infection, Severe Infection

Sponsor: Hospices Civils de Lyon

Locations: 1 active-listed location

Phage Therapy for Recurrent UTIs in Kidney Transplant Recipients

Trial ID: NCT06409819   Registry: ClinicalTrials.gov

Intervention: phage therapy, control

Condition: Urinary Tract Infection, Recurrent

Sponsor: University of California, San Diego

Locations: 1 active-listed location

Phase 1b/2a Randomized Double-blind Study to Investigate Safety Tolerability PK PD Preliminary Efficacy of Oral Administration of SNIPR001 in Patients With Hematologic Malignancy Scheduled for Allogeneic Hematopoietic Stem-Cell Transplant Receiving FQ Prophylaxis & Harboring FQR Ecoli Pre-Transplant

Trial ID: NCT06938867   Registry: ClinicalTrials.gov

Intervention: SNIPR001 consists of genetically modified bacteriophages specifically targeting Escherichia coli, Placebo 10 mL

Condition: E Coli Infections, Allogenic Transplant Patients

Sponsor: SNIPR Biome Aps.

Locations: 8 active-listed locations

PrePhage - Faecal Bacteriophage Transfer for Enhanced Gastrointestinal Tract Maturation in Preterm Infants

Trial ID: NCT05272579   Registry: ClinicalTrials.gov

Intervention: Fecal Filtrate Transfer, Placebo

Condition: Necrotizing Enterocolitis, Microbial Substitution

Sponsor: Rigshospitalet, Denmark

Locations: 1 active-listed location

Rapid Research in Diagnostics Development for TB Network

Trial ID: NCT04923958   Registry: ClinicalTrials.gov

Intervention: Novel mycobacterial culture techniques, Novel sputum smear microscopy techniques, Sputum-based molecular assays, Tongue swab-based molecular assays, Urine LAM assays, Blood-based host immune response assays, Breath-based assays, Artificial intelligence-based digital health tools, Phage-based assays, Cartridge-based molecular assays for detecting drug resistance, Sequencing-based assays for detecting drug resistance

Condition: Tuberculosis

Sponsor: University of California, San Francisco

Locations: 16 active-listed locations

Study With Phage for CF Subjects With Pseudomonas Lung Infection

Trial ID: NCT06998043   Registry: ClinicalTrials.gov

Intervention: BX004, Placebo

Condition: Chronic Pseudomonas Aeruginosa Infection, Cystic Fibrosis (CF)

Sponsor: BiomX Ltd

Locations: 14 active-listed locations