BACTERIOPHAGE THERAPY IS AN ALTERNATIVE TO ANTIBIOTICS

With the increasing problem of antimicrobial resistance, the efficacy of conventional antibiotics has been greatly reduced,necessitating new approaches to manage bacterial infections. Recently ,bacteriophage therapy has been re-emphasized as a potential biological strategy because of the ability of bacteriophages to selectively infect and kill pathogenic bacteria with minimal disturbance to the normal microbial community .Recent studies have shown the potential of phages to control the growth of multidrug resistant pathogens,degrade bacterial bioflim and improve treatments outcomes when adminstered alone or in combination with antibiotics. Recent advances in phage engineering ,adaptive evolution and personalized phage formulation have further enhanced their therapeutic potential and widened their spectrum of activity. Despite these promising developments, there are still a number of challenges to be addressed ,such as narrow host range,Emergence of phage resistance bacterial mutants ,standardization of manufacturing processes ,regulatory approval and need of strong clinical evidence .In general the review give aa logical overview of the current development status of phage therapy, discussing mechanisms,therapeutic applications ,recent technological advances, limitations ,and future prospects. In general , bacteriophage therapy is a promising adjunct or alternative to conventional antibiotics and may make a significant contribution to the global challenges of antimicrobial resistance .